DR. DAVID SINCLAIR: THE BIOLOGY OF SLOWING & REVERSING AGING

Listen: YouTube | Apple Podcasts | Spotify https://www.youtube.com/watch?v=n9IxomBusuwIn this episode, Dr. Huberman is joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don’t Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.In this interview, Dr. Huberman and Dr. Sinclair discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. They discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. They also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. Dr. Huberman and Dr. Sinclair discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And they discuss the key blood markers everyone should monitor to determine their biological versus chronological age. They also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. TIMESTAMPS 00:10:23 What Causes Aging? The Epigenome 00:15:53 Cosmetic Aging 00:17:15 Development Never Stops, Horvath Clock 00:20:12 Puberty Rate as a Determinant of Aging Rate 00:23:00 Fasting, Hunger & Food Choices 00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy 00:34:50 Caffeine, Electrolytes 00:35:56 Blood Glucose & the Sirtuins; mTOR 00:37:55 Amino Acids: Leucine, “Pulsing” 00:44:35 Metformin, Berberine 00:50:29 Resveratrol, Wine 00:53:20 What Breaks a Fast? 00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing 01:09:10 Are Artificial Sweeteners Bad for Us? 01:12:04 Iron Load & Aging 01:15:05 Blood Work Analysis 01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary 01:26:02 Amino Acids, Plants, Antioxidants 01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen 01:40:35 Neuroplasticity & Neural Repair 01:46:19 Ice Baths, Cold Showers, “Metabolic Winter” 01:48:07 Obesity & How It Accelerates Aging, GnRH 01:52:10 Methylation, Methylene Blue, Cigarettes 01:56:17 X-Rays 01:59:00 Public Science Education, Personal Health 02:05:40 The Sinclair Test You Can Take 02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram Published December 27, 2021 Source: Huberman Lab We Stock the following products: BUY NOW >> BUY NOW >> Previous Previous Medical cannabis producer Cilo Cybin first in South Africa to launch locally manufactured cannabinoid products with 400-500% higher absorption rate Next Next First African Cannabis SPAC Planned by Cilo Cybin Founder Theron SITEMAP